[1]林创廷 卢松耀 黄翔 郭少桢.宫内发育迟缓与新生儿血糖和血脂代谢水平的关系及影响[J].中华肥胖与代谢病电子杂志,2019,(01):26-30.[doi:DOI:10.3877/cma.j.issn.2095-9605.2019.01.005]
 Lin Chuangting,Lu Songyao,Huang Xiang,et al.Relationship between intrauterine growth retardation and neonatal blood glucose and lipid metabolism.[J].Chinese Journal of Obesity and Metabolic Disease (Electronic Edition),2019,(01):26-30.[doi:DOI:10.3877/cma.j.issn.2095-9605.2019.01.005]
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宫内发育迟缓与新生儿血糖和血脂代谢水平的关系及影响()
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《中华肥胖与代谢病电子杂志》[ISSN:2095-9605/CN:11-9362]

卷:
期数:
2019年01期
页码:
26-30
栏目:
论著
出版日期:
2019-04-28

文章信息/Info

Title:
Relationship between intrauterine growth retardation and neonatal blood glucose and lipid metabolism.
作者:
林创廷 1 卢松耀 2 黄翔 1 郭少桢
522000 揭阳,揭阳市人民医院新生儿科1 ;揭阳市人民医院检验科
Author(s):
Lin Chuangting1 Lu Songyao2 Huang Xiang1 Guo Shaozhen1 .
Department of Neonatology, Jieyang People's Hospital; 2 Department of Clinical Laboratory, Jieyang People's Hospital, Jieyang, Guangdong 522000, China
关键词:
宫内发育迟缓 出生体重 血糖 血脂 胰岛素
Keywords:
Intrauterine growth restriction Birth weight Blood sugar Blood lipids Insulin
DOI:
DOI:10.3877/cma.j.issn.2095-9605.2019.01.005
摘要:
目的 探讨宫内发育迟缓(IUGR)对新生儿血糖和血脂代谢的影响。方法 回顾性分 析2014年10月至2018年10月于揭阳市人民医院出生诊断为IUGR的新生儿共113例(IUGR组),选择非 IUGR新生儿共80例作为对照,对比两组新生儿的出生后体格发育指标、血糖和血脂指标以及胰岛素 敏感性和抵抗性。结果 IUGR组的新生儿出生体重、身长、头围、腹围和体重/身长的值均显著低于非 IUGR组,IUGR组和非IUGR组的FG、TG、TC水平对比差异均无统计学意义(P>0.05),IUGR组的ISI指 数显著低于非IUGR组(t=4.317,P<0.001),而IUGR组的HOMA-IR指数显著高于非IUGR组(t=4.013, P<0.001),新生儿的出生体重与FG、TG、TC水平没有显著的相关性(P>0.05),而与ISI指数呈显著的 正相关(r=0.479,P<0.001),与HOMA-IR指数呈显著的负相关(r=-0.642,P<0.001)。结论 IUGR新 生儿其胰岛素敏感性下降,胰岛素抵抗性增加,且其出生体重与胰岛素敏感性和抵抗性密切相关。
Abstract:
Objective To investigate the effects of intrauterine growth retardation on neonatal blood glucose and lipid metabolism. Methods A total of 113 neonates (IUGR group) diagnosed with IUGR at the Jieyang People's Hospital from March 2016 to February 2018 were retrospectively analyzed. A total of 80 non-IUGR neonates were selected as controls. To compare the postnatal physical development indicators, blood glucose and blood lipid indicators, and insulin sensitivity and resistance in the two groups of newborns. The ISI index of the IUGR group was significantly lower than that of the non-IUGR group, and the difference was statistically significant (t=4.317, P<0.001). Results The birth weight, length, head circumference, waist circumference, and weight/length of the newborns in the IUGR group were significantly lower than those in the non-IUGR group. There were no significant differences in FG, TG and TC levels between the IUGR group and the non-IUGR group (P>0.05). The ISI index of the IUGR group was significantly lower than that of the non-IUGR group, and the difference was statistically significant (t= 4.317, P<0.001). The HOMA-IR index of the IUGR group was significantly higher than that of the non-IUGR group (t=4.013, P <0.001). There was no significant correlation between the birth weight of newborns and FG, TG and TC levels (P>0.05), but a significant positive correlation with ISI index (r=0.479, P<0.001), and HOMA-IR. The number showed a significant negative correlation (r=-0.642, P<0.001). Conclusions IUGR neonates have decreased insulin sensitivity, increased insulin resistance, and their birth weight is closely related to insulin sensitivity and resistance.

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更新日期/Last Update: 2019-04-28