[1]张春明 张光辉.腹腔镜Roux-en-Y 胃旁路术在治疗2 型糖尿病中的应用价值[J].中华肥胖与代谢病电子杂志,2016,2(01):22-25.[doi:10.3877//cma.j.issn.2095-9605.2016.01.005]
 ZhangChunming,Zhang Guanghui..Application value of laparoscopic Roux-en-Y gastric bypass in treating type 2 diabetes mellitus[J].Chinese Journal of Obesity and Metabolic Disease (Electronic Edition),2016,2(01):22-25.[doi:10.3877//cma.j.issn.2095-9605.2016.01.005]
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腹腔镜Roux-en-Y 胃旁路术在治疗2 型糖尿病中的应用价值()
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《中华肥胖与代谢病电子杂志》[ISSN:2095-9605/CN:11-9362]

卷:
第2卷
期数:
2016年01期
页码:
22-25
栏目:
临床研究
出版日期:
2016-03-30

文章信息/Info

Title:
Application value of laparoscopic Roux-en-Y gastric bypass in treating type 2 diabetes mellitus
作者:
张春明1 张光辉2
450006 郑州市第三人民医院普外科1 ;450000 郑州市第二人民医院普外科2
Author(s):
ZhangChunming1 Zhang Guanghui2. 1
1Department of General Surgery, the Third People’s Hospital of Zhengzhou,Zhengzhou 45006, China; 2Department of General Surgery, the Second People’s Hospital of Zhengzhou,Zhengzhou 45000, ChinaCorresponding author: Zhang Chunming, Email:892935023@qq.com
关键词:
腹腔镜Roux-en-Y胃旁路术 2型糖尿病 治疗结果
Keywords:
Laparoscopic Roux-en-Y gastric bypass Type 2 diabetes mellitus Treatmentoutcome
DOI:
10.3877//cma.j.issn.2095-9605.2016.01.005
摘要:
目的 探讨腹腔镜Roux-en-Y胃旁路术(laparoscopic Roux-en-Y gastric bypass,LRYGB)在治疗2型糖尿病(type 2 diabetes mellitus,T2DM)中的应用价值。方法 回顾性分析2009年2月至2013年10月在郑州市第二人民医院和郑州市第三人民医院接受LRYGB治疗的36例T2DM患者的临床资料。所有患者均签署知情同意书,符合医学伦理学规定。其中男26例,女10例;年龄(55±12)岁;平均体质指数(body mass index,BMI)( 28.1±5.0)kg/m2,平均空腹血糖(fasting plasma glucose,FPG)( 12.4±3.8)mmol/L,平均糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)(8.7±0.7)%。术前和术后6个月对所有患者的BMI、FPG、糖耐量实验2小时血糖、HbA1c、胰岛素抵抗指数、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平进行检测。手术前后临床指标的比较采用t检验。结果 LRYGB后6个月,患者的FPG水平为(6.0±1.1)mmol/L,明显低于术前的(12.4±3.8)mmol/L(t=2.675, P<0.05);HbA1c水平为(6.2±0.2)%,明显低于术前的(8.7±0.7)%(t=4.135, P<0.05);TC水平为(4.3±0.4)mmol/L,明显低于术前的(5.8±1.3)mmol/L(t=2.178,P<0.05);患者合并的高血压病、脂肪肝、高脂血症均得到不同程度的改善。结论 LRYGB对T2DM有良好的近期治疗效果,远期疗效有待于进一步观察。
Abstract:
Objective To investigate the clinical application value of laparoscopic Roux-en-Ygastric bypass (LRYGB) in treating type 2 diabetes mellitus. Methods Clinical data of 36 patientsundergoing LRYGB in the Second People’s Hospital and the Third People’s Hospital of Zhengzhou fromFebruary 2009 to October 2013 were analyzed retrospectively. The informed consents of all patients wereobtained and the ethical committee approval had been received. Among the 36 patients, 26 were males and10 were females with an average age of (55±12) years old, an average body mass index (BMI) of (28.1±5.0) kg/m2,an average fasting plasma glucose (FPG) of (12.4±3.8) mmol/L and an average glycosylated hemoglobinA1c (HbA1c) of (8.7±0.7)%. BMI, FPG, 2 h blood glucose of oral glucose tolerance test, HbAlc, insulinresistance index, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C)were tested for all patients before and 6 months after surgery. Clinical indexes before and after operationwere compared using t test. Results At 6 months after LRYGB, FPG level was (6.0±1.1) mmol/L, whichwas significantly lower than (12.4±3.8) mmol/L before operation (t=2.675, P<0.05); HbA1c level was(6.2±0.2)%, which was significantly lower than (8.7±0.7)% before operation (t=4.135, P<0.05); andTC level was (4.3±0.4) mmol/L, lower than (5.8±1.3) mmol/L before operation (t=2.178, P<0.05). The comorbidities of hypertension, fatty liver and hyperlipidemia got different degrees of remission.Conclusions LRYGP has a good short-term curative effect on treating T2DM, but the long-term curativeeffect remains to be observed.

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备注/Memo

备注/Memo:

通讯作者:张春明,Email:892935023@qq.com
更新日期/Last Update: 2016-03-30