[1]韩辉 范国聚 高宏凯 杨晓莉 郭静 邹德勇 张丽萍 张野.腹腔镜胃旁路术后肥胖型2型糖尿病患者血清脂联素水平的变化[J].中华肥胖与代谢病电子杂志,2015,1(01):34-38.[doi:10.3877/cma.j.issn.2095-9605.2015.01.009]
 Han Hui,Fan Guoju,Gao Hongkai,et al.The analysis of changing about serum adiponectin in obese patients with type 2 diabetes after laparoscopic gastric bypass[J].Chinese Journal of Obesity and Metabolic Disease (Electronic Edition),2015,1(01):34-38.[doi:10.3877/cma.j.issn.2095-9605.2015.01.009]
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腹腔镜胃旁路术后肥胖型2型糖尿病患者血清脂联素水平的变化()
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《中华肥胖与代谢病电子杂志》[ISSN:2095-9605/CN:11-9362]

卷:
第1卷
期数:
2015年01期
页码:
34-38
栏目:
临床研究
出版日期:
2015-03-30

文章信息/Info

Title:
The analysis of changing about serum adiponectin in obese patients with type 2 diabetes after laparoscopic gastric bypass
作者:
韩辉 范国聚 高宏凯 杨晓莉 郭静 邹德勇 张丽萍 张野
100039 北京,武警总医院普外科
Author(s):
Han Hui Fan Guoju Gao Hongkai Yang Xiaoli Guo Jing Zou Deyong Zhang Liping Zhang Ye.
Department of General Surgery, Armed Police General Hospital, Beijing 100039, China
关键词:
腹腔镜Roux-en-Y胃旁路术 糖尿病2型 肥胖症 脂联素
Keywords:
Laparoscopic Roux-en-Y gastric bypass Diabetes mellitus Type 2 Obesity Adiponectin
DOI:
10.3877/cma.j.issn.2095-9605.2015.01.009
摘要:
目的 研究肥胖型2型糖尿病患者在腹腔镜胃旁路术(laparoscopic Roux-en-Y gastric bypass,LRYGB)前后血清脂联素水平的变化。方法 2011年3月至2012年2月期间,武警总医院普通外科共收治52例肥胖型2型糖尿病(type 2 diabetes mellitus,T2DM)患者,均实施LRYGB,术后随访1年,于术前和术后1周、1个月、3个月、6个月和1年分别进行血清脂联素、糖化血红蛋白、甘油三酯和胆固醇水平的检测及行OGTT、胰岛素释放试验等。以上临床指标的比较采用完全随机设计的方差分析。结果 随访率为100%,无失访病例;1年随访期间T2DM的治愈率为86.5%,肥胖症治愈率为67.3%;与术前空腹脂联素的平均水平4.3 mg/L相比,术后3个月内脂联素水平稍有下降,下降至2.93 mg/L,而后逐渐升高至7.36 mg/L,术后12个月水平与术前比较差异有统计学意义(P<0.05);术后空腹血糖、糖化血红蛋白、胰岛素抵抗指数水平均较术前呈持续下降趋势,且术后12个月水平与术前比较差异有统计学意义(P<0.05)。结论 LRYGB治疗肥胖型T2DM有确切疗效,术后脂联素水平升高可能与术后糖代谢改善的机制相关。
Abstract:
Objective To investigate the changing of serum adiponectin in obese patients with T2DM who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods From March 2011 to February 2012,52 obese patients with T2DM were admitted to Armed Police General Hospital and underwent LRYGB. The follow-up time is one year. Adiponectin, HbA1c, triglycerides, cholesterol, OGTT and insulin release test were detected in postoperative time of 1 week and 1, 3, 6, 12 months. Results The follow-up rate is 100% with no loss; During the one-year follow-up, the cure rate of T2DM was 86.5% (45/52) and the cure rate of obesity was 67.3% (35/52); Comparing with the mean level of 4.3 ug/ml of adiponectin pre-operatively, adiponectin decreased to 2.93 ug/ml slightly within 3 months follow-up, then increased gradually to 7.36 ug/ml, the level of 12 months after procedures had a statistical difference comparing to the preoperative level (P<0.05); the levels of FPG, HbA1c and HOMA-IR decreased continuously, and had statistical differences comparing to the preoperative levels (P<0.05). Conclusions LRYGB has exact treating effectiveness for obese patients with T2DM,and the increased level of adiponectin after procedures may be related to the mechanism of improvement of glucose metabolism.

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备注/Memo:

通讯作者:高宏凯,Email:wjgaohk@163.com
更新日期/Last Update: 2015-05-30